Evaluation of progestogen supplementation for luteal phase support in fresh in vitro fertilization cycles

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Luteal phase support in in vitro fertilization.

It has been well demonstrated that luteal phase physiology is disrupted in in vitro fertilization (IVF) cycles conducted with either gonadotropin-releasing hormone (GnRH) agonists or antagonists, and that supplementation of the luteal phase with either exogenous progesterone or human chorionic gonadotropin (hCG) is necessary to optimize IVF cycle outcomes. Though both progesterone and hCG suppl...

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Estrogen Supplementation to Progesterone as Luteal Phase Support in Patients Undergoing In Vitro Fertilization

Meta-analyses have found conflicting results with respect to the use of progesterone or progesterone plus estrogen as luteal phase support for in vitro fertilization (IVF) protocols involving gonadotropins and/or gonadotropin-releasing hormone analogs. The aim of the present study was to perform an updated meta-analysis on the efficacy of progesterone versus progesterone plus estrogen as luteal...

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Luteal estradiol supplementation in gonadotropin-releasing hormone antagonist cycles for infertile patients in vitro fertilization

OBJECTIVE To evaluate the effect of the addition of estradiol to luteal progesterone supplementation in GnRH antagonist cycles for infertile patients undergoing IVF/ICSI. METHODS One hundred and ten infertile patients, aged 28 to 39 years, were recruited for this prospective randomized study. They were randomly assigned to receive vaginal progesterone gel (Crinone) along with 4 mg estradiol v...

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Phase III trial of 8% vaginal progesterone gel for luteal phase support in Japanese women undergoing in vitro fertilization and fresh embryo transfer cycles

Aim This study evaluated the efficacy and safety of vaginal progesterone gel that was administered daily for luteal phase support as part of in vitro fertilization/embryo transfer (IVF/ET) cycles in Japanese women. Methods This was a phase III, multicenter, open-label, single-arm trial in Japanese women undergoing IVF/ET, using the Japanese Society of Obstetrics and Gynecology 2009 registry a...

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I-31: New Approaches for Luteal Phase Support in ART Cycles

Background During a normal menstrual cycle, progesterone prepares the endometrium for pregnancy by stimulating proliferation in response to human chorionic Gnadotropin produced by the corpus luteum. Many questions were raised about the role of follicular fluid aspiration on the granuloma cells at the time of oocyte retrieving during the ART cycles. Authors believes that oocyte retrieval might d...

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ژورنال

عنوان ژورنال: Fertility and Sterility

سال: 2019

ISSN: 0015-0282

DOI: 10.1016/j.fertnstert.2019.04.021